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KMID : 0364820180540040448
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Korean Journal of Microbiology
2018 Volume.54 No. 4 p.448 ~ p.452
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The complete genome sequence of a marine sponge-associated bacteria, Bacillus safensis KCTC 12796BP, which produces the anti-allergic compounds
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Hanh Nguyen Phan Kieu
Kim Soo-Hee
Kim Geum-Jin
Choi Hyuk-Jae
Nam Doo-Hyun
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Abstract
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The full genome sequence of Bacillus safensis KCTC 12796BPwhich had been isolated from the marine sponge in theseawater of Jeju Island, was determined by Pac-Bio nextgenerationsequencing system. A circular chromosome in thelength of 3,935,874 bp was obtained in addition to a circularform of plasmid having 36,690 bp. The G + C content ofchromosome was 41.4%, and that of plasmid was 37.3%. Thenumber of deduced CDSs in the chromosome was 3,980, whereas36 CDS regions were determined in a plasmid. Among thededuced CDSs in chromosome, 81 tRNA genes and 24 rRNAgenes in addition to one tmRNA were allocated. More than 30CDSs for sporulation, 16 CDSs for spore coat, and 20 CDSs forgermination were also assigned in the chromosome. Severalgenes for capsular polysaccharide biosynthesis and for flagellabiosynthesis and chemotaxis in addition to genes for osmotictolerance through glycine-choline betaine pathway were alsoidentified. Above all, the biosynthetic gene cluster for antiallergiccompounds seongsanamides were found among twonon-ribosomal peptide synthetase (NRPS) gene clusters forsecondary metabolites.
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KEYWORD
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Bacillus safensis, genome sequence, marine bacteria, non-ribosomal peptide synthetase, seongsanamide
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